ERYTHROPHAGOCYTOSIS AND ITS RELATION TO BAND-3 CLUSTERING IN CHRONIC MYELOGENOUS LEUKEMIA

Authors
DAS AK SINHA AK BASU J
Citation
Ak. Das et al., ERYTHROPHAGOCYTOSIS AND ITS RELATION TO BAND-3 CLUSTERING IN CHRONIC MYELOGENOUS LEUKEMIA, Biochemistry and molecular biology international, 41(3), 1997, pp. 539-545
Citations number
25
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
41
Issue
3
Year of publication
1997
Pages
539 - 545
Database
ISI
SICI code
1039-9712(1997)41:3<539:EAIRTB>2.0.ZU;2-Q
Abstract
Band 3, a major erythrocyte membrane glycoprotein, undergoes topograph ic redistribution leading to enhanced clustering, in chronic myelogeno us leukemia (CML). This is probably due to the binding of heme compoun ds to the CML erythrocyte membrane resulting from depletion of cellula r levels of reduced glutathione (GSH). Band 3 clustering appears to be one of the factors associated with increased erythrophagocytosis in C ML.