Ck. Ritchie et al., EFFECTS OF THE CALCIOTROPHIC PEPTIDES CALCITONIN AND PARATHYROID-HORMONE ON PROSTATE-CANCER GROWTH AND CHEMOTAXIS, The Prostate, 30(3), 1997, pp. 183-187
BACKGROUND. The most common site of metastases in prostate cancer is t
he skeleton and occurs in 70-80% of patients with prostate carcinoma.
Calciotrophic peptides are important in the growth and development of
normal bone matrix. METHODS. Three human prostate carcinoma cells line
s, DU-145, PC-3, and LNCaP, were exposed to varying concentrations of
parathyroid hormone (PTH) or calcitonin (CT). Cell proliferation and c
hemotaxis were assessed. RESULTS. Proliferation increased in LNCaP cel
ls in a dose-dependent manner following treatment with PTH. Proliferat
ion was not altered in PC-3 cells in response to PTH. Proliferation wa
s decreased in DU-145 and PC-3 cells and increased in LNCaP cells afte
r treatment with CT. Cell chemotaxis was increased in the presence of
PTH in DU-145 and PC-3 cells compared to vehicle-treated controls. CON
CLUSIONS. The combined proliferation and chemotaxis data suggest that
PTH has a dual role in prostate carcinoma resulting in an increase in
the number and migration of selected prostate cancer cells. With CT, c
hemotaxis was unchanged in the DU-145 and PC-3 cells and significantly
elevated in the LNCaP cell line. The calciotrophic hormones, PTH and
CT, may play an integral role in the regulation of prostate cell growt
h and metastases. (C) 1997 Wiley-Liss, Inc.