Cryptosporidium parvum, a leading cause of persistent diarrhea in deve
loping countries, is a major threat to the U.S. water supply. Able to
infect with as few as 30 microscopic oocysts, Cryptosporidium is found
in untreated surface water, as well as in swimming and wade pools, da
y-care centers, and hospitals. The organism can cause illnesses lastin
g longer than 1 to 2 weeks in previously healthy persons or indefinite
ly in immunocompromised patients; furthermore, in young children in de
veloping countries, cryptosporidiosis predisposes to substantially inc
reased diarrheal illnesses. Recent increased awareness of the threat o
f cryptosporidiosis should improve detection in patients with diarrhea
. New methods such as those using polymerase chain reaction may help w
ith detection of Cryptosporidium in water supplies or in asymptomatic
carriers. Although treatment is very limited, new approaches that may
reduce secretion or enhance repair of the damaged intestinal mucosa ar
e under study.