OPTICAL RESOLUTION BY PREFERENTIAL CRYSTALLIZATION OF DL-METHIONINE HYDROCHLORIDE

Authors
SHIRAIWA T MIYAZAKI H WATANABE T KUROKAWA H
Citation
T. Shiraiwa et al., OPTICAL RESOLUTION BY PREFERENTIAL CRYSTALLIZATION OF DL-METHIONINE HYDROCHLORIDE, Chirality, 9(1), 1997, pp. 48-51
Citations number
10
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
9
Issue
1
Year of publication
1997
Pages
48 - 51
Database
ISI
SICI code
0899-0042(1997)9:1<48:ORBPCO>2.0.ZU;2-B
Abstract
DL-Methionine hydrochloride (DL-Met . HCl) was found to exist as a con glomerate, based on the infrared spectrum, solubility, and melting poi nt. The optical resolution of DL-Met . HCl was successfully achieved b y preferential crystallization into D- and L-Met . HCl. Treatment of t he purified D- and L-Met . HCl with triethylamine gave D- and L-methio nine of 100% optical purities. (C) 1997 Wiley-Liss, Inc.