ANTICONVULSANT EFFECT OF SL-75-102 IN ADULT AND IMMATURE RATS

Authors
KUBOVA H HAUGVICOVA R MARES P
Citation
H. Kubova et al., ANTICONVULSANT EFFECT OF SL-75-102 IN ADULT AND IMMATURE RATS, Physiologia bohemoslovaca, 46(1), 1997, pp. 73-76
Citations number
16
Journal title
Physiologia bohemoslovaca → ACNP
ISSN journal
03699463
Volume
46
Issue
1
Year of publication
1997
Pages
73 - 76
Database
ISI
SICI code
0369-9463(1997)46:1<73:AEOSIA>2.0.ZU;2-R
Abstract
The anticonvulsant action of SL 75 102, a metabolite of Progabide, was studied in a model of pentylenetetrazol-induced motor seizures in adu lt and 12-day-old rats. SL 75 102 suppressed generalized tonic-clonic seizures in adult rats and restricted the tonic phase of these seizure s in rat pups. SL 75 102 was less effective than Progabide. In additio n, some minor differences in anticonvulsant actions of these two drugs were observed.