LIPOPROTEIN GLOMERULOPATHY - A PEDIATRIC CASE-REPORT

We report an 8-year-old girl with lipoprotein glomerulopathy who may h ave developed this condition as young as 4 years of age, To our knowle dge this is the youngest reported case of this disease. Lipid studies of the patient and her family members revealed elevated concentrations of apolipoprotein E (ape E), the apo E phenotype E2/3, and the genoty pe E3/3. However, other families revealed no urinary abnormalities, Ou r findings suggest that an apo E abnormality may be responsible for th e development of lipoprotein glomerulopathy, Genetic analysis of apo E is needed to clarify the pathogenesis.