A MULTICENTER, PARALLEL COMPARATIVE-STUDY OF THE ANTIHYPERTENSIVE EFFICACY OF ONCE-DAILY LISINOPRIL VS ENALAPRIL WITH 24-H AMBULATORY BLOOD-PRESSURE MONITORING IN ESSENTIAL-HYPERTENSION

The aim of the study was to compare the antihypertensive efficacy of o nce-daily lisinopril vs enalapril both during normal daily activity an d sleep, in mild-to-moderate essential hypertension, After a 4-week wa sh-out period, 34 patients (17 M, 17 F) aged 22 to 67 years were rando mized in a multicenter, open, parallel fashion: 17 received lisinopril (10-20 mg) and 17 enalapril (10-20 mg) for a 12-week period. Twenty-f our hour ambulatory blood pressure monitoring (ABPM) was performed usi ng an oscillometric non-invasive automated device at both the end of t he 4-week drug-free baseline period and during the last week of treatm ent, With no differences in initial blood pressure (BP) between groups , both drugs significantly reduced office and ABPM values, Lisinopril tended to reduce BP in a greater extension than enalapril, but only th e reduction of office systolic BP (SEP) (P = 0.0062), 24-h SBP load (P = 0.0182) and night time SBP load (P = 0.0316) reached statistical si gnificance. We conclude that, in spite of a more prominent reduction o f SBP by lisinopril, both drugs have a similar efficacy in reducing BP , assessed by both office and ABPM measurements.