PYRIDINDOLOLS K1 AND K2, NEW ALKALOIDS FROM STREPTOMYCES SP K93-0711

Authors
KIM YP TAKAMATSU S HAYASHI M KOMIYAMA K OMURA S
Citation
Yp. Kim et al., PYRIDINDOLOLS K1 AND K2, NEW ALKALOIDS FROM STREPTOMYCES SP K93-0711, Journal of antibiotics, 50(3), 1997, pp. 189-193
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
3
Year of publication
1997
Pages
189 - 193
Database
ISI
SICI code
0021-8820(1997)50:3<189:PKAKNA>2.0.ZU;2-0
Abstract
Two new alkaloids with the beta-carboline skeleton, pyridindolols K1 ( C18H18N2O5) and K2 (C16H16N2O4), were isolated from the culture broth of Streptomyces sp. K93-0711. The structure of pyridindolols were esta blished by spectroscopic investigations and chemical transformations. Pyridindolol K2 inhibited the adhesion of HL-60 cells to LPS-activated HUVEC monolayer (IC50 = 75 mu g/ml).