A CONTROLLED TRIAL OF AMANTADINE HYDROCHLORIDE AND NEUROLEPTICS IN THE TREATMENT OF TARDIVE-DYSKINESIA

Authors
ANGUS S SUGARS J BOLTEZAR R KOSKEWICH S SCHNEIDER NM
Citation
S. Angus et al., A CONTROLLED TRIAL OF AMANTADINE HYDROCHLORIDE AND NEUROLEPTICS IN THE TREATMENT OF TARDIVE-DYSKINESIA, Journal of clinical psychopharmacology, 17(2), 1997, pp. 88-91
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Psychiatry,"Clinical Neurology
Journal title
Journal of clinical psychopharmacology → ACNP
ISSN journal
02710749
Volume
17
Issue
2
Year of publication
1997
Pages
88 - 91
Database
ISI
SICI code
0271-0749(1997)17:2<88:ACTOAH>2.0.ZU;2-6
Abstract
An 18-week, double-blind, crossover study of amantadine and neurolepti es in the treatment of tardive dyskinesia (TD) is described. A fixed-d ose regimen was used, and objective rating scales for TD, extrapyramid al symptoms, and mental state were employed. The results indicate that amantadine is significantly better than placebo in the management of TD and that there is little risk of exacerbating psychosis. Further in vestigation of this potentially useful medication is warranted.