Four brain-injured subjects with semantic memory impairments are descr
ibed. Two had sustained traumatic head injury and two had herpes simpl
ex virus encephalitis. The study seeks to determine (a) whether subjec
ts with non-progressive brain injury and impaired semantic memory perf
orm similarly to patients with progressive disorders on a semantic mem
ory battery and (b) whether the anatomical lesions of the present grou
p of subjects are similar to those seen in patients with progressive d
isorders. Results suggests that scores on the semantic memory battery
are broadly similar for patients with progressive and non-progressive
disorders. Information from magnetic resonance imaging scans supports
other findings that the crucial area involved in semantic memory lies
in the left temporal neocortex.