SYNTHESIS AND MICROBIOLOGICAL EVALUATIONS OF (N-HETEROARYL)ARYLMETHANAMINES AND THEIR SCHIFF-BASES

The synthesis as well as the antimicrobial and antiviral activities of new (N-heteroaryl)arylmethanamines and their Schiff bases are reporte d. None of the tested compounds shown activity against Herpes simplex virus type 2 and against Gram positive and Gram negative bacteria. Wea k or moderate activity on poliovirus Sabin type 1, on reverse transcri ptase and against Cryptococcus neoformans was shown by some of the tes ted compounds. Viceversa several synthesized compounds exhibited a mod erate or good activity against strains of Candida albicans, while only some of the tested compounds were found moderately active against str ains of Candida sp. Instead numerous new compounds 3 or 4 were active as control against isolates of plant pathogenic fungi. The obtained re sults are discussed on the basis of structure-activity relationships.