NUCLEAR RECEPTOR COACTIVATORS

Retinoic acid, steroid and thyroid hormones regulate complex programs of gene expression by binding to intracellular receptors that are memb ers of the nuclear receptor superfamily of ligand-dependent transcript ion factors. Recent studies have led to the identification and cloning of genes encoding coactivator molecules that appear to play important roles in mediating ligand-dependent transcription by members of this family, The identification of these coactivator molecules suggests a p aint of entry into the general transcriptional machinery that is commo n to several other classes of regulated transcription factors.