SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 5,6-DIHYDROBENZO[F] CINNOLIN-2(3H)ONES ANALOGS OF ANTIHYPERTENSIVE AND ANTIAGGREGATING BENZO[H]CINNOLINONES

Authors
PINNA GA CURZU MM FRAGHI P GAVINI E DAMICO M
Citation
Ga. Pinna et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 5,6-DIHYDROBENZO[F] CINNOLIN-2(3H)ONES ANALOGS OF ANTIHYPERTENSIVE AND ANTIAGGREGATING BENZO[H]CINNOLINONES, Il Farmaco, 51(10), 1996, pp. 653-658
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
10
Year of publication
1996
Pages
653 - 658
Database
ISI
SICI code
0014-827X(1996)51:10<653:SAPEO5>2.0.ZU;2-R
Abstract
Two new dihydrobenzo[f]cinnolin-2(3H)ones (4a,b) have been synthesized and tested for their hypothensive, antihypertensive and antiaggregati ng activities in comparison with the lead 8-acetylamino-4,4a,5,6-tetra hydrobenzo [h]cinnolin-3(2H)-one 1. In vivo tests indicated that 4a,b displayed hypotensive and antihypertensive properties weaker than the model compound. On the contrary both compounds were more potent than 1 in inhibiting collagen-induced platelet aggregation.