3,6-DISUBSTITUTED 1,2,4-TRIAZOLO[3,4-B]THIADIAZOLES - SYNTHESIS, ANTIMICROBIAL AND ANTIVIRAL ACTIVITY .2.

Authors
INVIDIATA FP SIMONI D SCINTU F PINNA N
Citation
Fp. Invidiata et al., 3,6-DISUBSTITUTED 1,2,4-TRIAZOLO[3,4-B]THIADIAZOLES - SYNTHESIS, ANTIMICROBIAL AND ANTIVIRAL ACTIVITY .2., Il Farmaco, 51(10), 1996, pp. 659-664
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
10
Year of publication
1996
Pages
659 - 664
Database
ISI
SICI code
0014-827X(1996)51:10<659:31-SA>2.0.ZU;2-3
Abstract
A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadi azole derivatives was prepared and tested to evaluate their antimycoti c and antibacterial activities. Anti-HIV-1 activity has also been inve stigated. Among the test compounds, derivatives 10a-14a and 16c showed anti-HIV-1 activity at concentrations slightly below those cytotoxic. Substitutions at 3 and 6 positions seems to be important in lowering the cytotoxicity of compounds.