Oncogenic potentials of 11 strains of avian adenovirus representing 10
serotypes were investigated in 22 litters of 1-day-old Syrian hamster
s (Mesocricetus auratus). Hamsters were inoculated via two routes: sub
cutaneous dose of 0.1 ml and intracerebral dose of 0.02 ml. Six strain
s, Indiana-C (Ind-C), chicken embryo lethal orphan (CELO), Stein, 75-1
A, B-3, and A-2, induced fibrosarcomas subcuteously at the inoculation
site. Hamsters inoculated intracerebrally with Ind-C, CELO, Stein, B-
3, and A-2 developed carcinomas of the choroid plexus. Strain 75-1A vi
rus produced tumors on subcutaneous inoculation but failed to produce
tumors on intracerebral inoculation. The Tipton, J-2, T-8, C-2B, and X
-11 strains did not produce tumors in hamsters. Uninoculated control h
amsters did not develop tumors.