M. Kobus et al., PROTECTION AND THERAPY OF EXPERIMENTAL HERPESVIRUS INFECTIONS IN MICEWITH IMMUNOMODULATING PROPIONIBACTERIUM-AVIDUM KP-40 AND OR ACYCLOVIR/, Zentralblatt fur Bakteriologie, 285(3), 1997, pp. 445-449
Protection and therapy of NMRI mice with experimental herpes virus (HS
V-1) encephalitis were investigated using heat-killed, lyophilized Pro
pionibacterium avidum KP-40 (PAI and/or the herpes-specific antiviral
substance acyclovir (ACL) as immunomodifier. Poly I:C as a potent macr
ophage activator was used as a reference compound for PA. Survival of
experimental HSV-1 infections during 18 days following the inoculation
of viruses was used for the evaluation of the effects of immunotherap
y. The applied model of HSV-I infection resulted in a mortality of abo
ut 87% of NMRI mice at 7-16 days following the inoculation of the viru
s. Treatment with ACL or Poly I:C at the day of HSV-1 infection result
ed in a lowering of the mortality rate to about 40% (p < 0.05). PA app
lied 4 days before HSV-1 infection lowered the mortality rate to 27%,
while treatment 2 days after infection was less effective and the mort
ality rate reached 44%, although still being significantly lower (p <
0.01) than in untreated controls. A combined treatment with ACL and PA
on the day of HSV-1 infection protected 93% of animals against the de
velopment of clinically detectable herpesvirus encephalitis.