PYRIDAZINE N-OXIDES .1. SYNTHESIS AND IN-VITRO ANTIMICROBIAL EVALUATION OF 3-METHYL-4-ARYL-6-R-PYRIDAZINE N-OXIDES

Authors
GAVINI E JULIANO C MULE A PIRISINO G PINNA GA CURZU MM
Citation
E. Gavini et al., PYRIDAZINE N-OXIDES .1. SYNTHESIS AND IN-VITRO ANTIMICROBIAL EVALUATION OF 3-METHYL-4-ARYL-6-R-PYRIDAZINE N-OXIDES, Il Farmaco, 51(10), 1996, pp. 683-688
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
10
Year of publication
1996
Pages
683 - 688
Database
ISI
SICI code
0014-827X(1996)51:10<683:PN.SAI>2.0.ZU;2-F
Abstract
A new series of 3-methyl-4-aryl-6-R-pyridazine N-oxides 1a-j, structur ally related to known antifungal agents azoxybacilin and pyridazomycin , has been prepared and evaluated for their in vitro antimicrobial act ivity. Among the compounds synthesized only 1g and 1h showed a fair ac tivity against Gram-positive Staphylococcus epidermidis and Staphyloco ccus aureus.