SYNTHESIS OF THE 3-HOMOLOG OF IPRIFLAVONE

Authors
PIFFERI G DARE P VALENTI P BISI A
Citation
G. Pifferi et al., SYNTHESIS OF THE 3-HOMOLOG OF IPRIFLAVONE, Il Farmaco, 51(10), 1996, pp. 689-691
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
10
Year of publication
1996
Pages
689 - 691
Database
ISI
SICI code
0014-827X(1996)51:10<689:SOT3OI>2.0.ZU;2-Y
Abstract
The synthesis of 3-benzyl-7-isopropoxychromone (2), an homologue of ip riflavone, was performed by alkaline isomerization of the correspondin g 3-benzylidene derivative, obtained by crotonic condensation of 7-iso propoxychromanone with benzaldehyde. The ''in vitro'' stimulating acti vity of compound 2 on the osteoblast cell proliferation in comparison with IGF-1 and ipriflavone is also reported.