MAGNETIC-RESONANCE-IMAGING OF MYOCARDIAL-INFARCTION DURING PROTHROMBIN COMPLEX CONCENTRATE THERAPY OF HEMOPHILIA-A

In patients with hemophilia, prothrombin complex concentrates (PCCs) h ave been successfully used to bypass inhibitors to factor VIII during bleeding episodes, The use of PCCS, including FEIBA (factor eight inhi bitor bypassing activity), has been associated with thromboembolic com plications. Myorsardial infarction (MI) is a rare but serious complica tion, reported in 13 previous cases, six in the pediatric age group. T n all four patients who died during the acute MI, autopsy revealed ext ensive myocardial hemorrhage. The hearts of three other patients exami ned at least 5 months after the acute MI showed no evidence of prior h emorrhage, Magnetic resonance (MR) imaging has been shown to be able t o evaluate the sequelae of myocardial infarction in adults with corona ry artery disease and in children with Kawasaki syndrome. We report th e first case of the use of MR imaging in the evaluation of myocardial damage during the acute stage of a FEIBA-associated MI in a 10-year-ol d boy.