INTRACRANIAL VASCULAR CALCIFICATIONS, GLIOBLASTOMA-MULTIFORME, AND LEAD-POISONING

A 72-year-man with previous lead poisoning presented with raised intra cranial pressure and localizing neurologic signs. CT scans showed a hi gh-grade glioma and extensive intracranial calcifications, which prove d to be vascular in distribution on postmortem examination. The latter findings support the concept of dystrophic calcification following le ad-induced cerebrovascular injury, Lead poisoning should be considered in the differential diagnosis of unexplained intracranial calcificati ons, There is also evidence from previous studies to suggest a causati ve relationship between lead poisoning and development of glioma.