MAPPING OF PEPTIDIC EPITOPES OF GLYCOPHORIN-A (GPA) AND GLYCOPHORIN-C(GPC) WITH PEPTIDES SYNTHESIZED ON PLASTIC PINS (PEPSCAN ANALYSIS)

Authors
WASNIOWSKA K JASKIEWICZ E CZERWINSKI M SYPER D LISOWSKA E
Citation
K. Wasniowska et al., MAPPING OF PEPTIDIC EPITOPES OF GLYCOPHORIN-A (GPA) AND GLYCOPHORIN-C(GPC) WITH PEPTIDES SYNTHESIZED ON PLASTIC PINS (PEPSCAN ANALYSIS), Transfusion clinique et biologique, 4(1), 1997, pp. 73-75
Citations number
4
Categorie Soggetti
Hematology,Immunology
Journal title
Transfusion clinique et biologique → ACNP
ISSN journal
12467820
Volume
4
Issue
1
Year of publication
1997
Pages
73 - 75
Database
ISI
SICI code
1246-7820(1997)4:1<73:MOPEOG>2.0.ZU;2-0
Abstract
The peptidic epitopes of 12 anti-CPA and 4 anti-GPC antibodies were id entified with the use of peptides synthesized on the pins. Most of the antibodies were specific for epitopes located in extracellular portio n of glycophorins, and only 2 anti-CPA and 1 anti-CPC recognized epito pes in their C-terminal cytoplasmic tails. The extracellular GPA epito pes were located in two regions of the polypeptide chain, within a.a. residues 38-44 and 49-58.