IN-VITRO ACTIVITY OF FOSFOMYCIN COMBINED WITH CEFTAZIDIME, IMIPENEM, AMIKACIN, AND CIPROFLOXACIN AGAINST PSEUDOMONAS-AERUGINOSA

Authors
TESSIER F QUENTIN C
Citation
F. Tessier et C. Quentin, IN-VITRO ACTIVITY OF FOSFOMYCIN COMBINED WITH CEFTAZIDIME, IMIPENEM, AMIKACIN, AND CIPROFLOXACIN AGAINST PSEUDOMONAS-AERUGINOSA, European journal of clinical microbiology & infectious diseases, 16(2), 1997, pp. 159-162
Citations number
16
Categorie Soggetti
Microbiology,"Infectious Diseases
Journal title
European journal of clinical microbiology & infectious diseases → ACNP
ISSN journal
09349723
Volume
16
Issue
2
Year of publication
1997
Pages
159 - 162
Database
ISI
SICI code
0934-9723(1997)16:2<159:IAOFCW>2.0.ZU;2-V
Abstract
The in vitro activity of fosfomycin in combination with ceftazidime, i mipenem, amikacin, or ciprofloxacin was studied by an agar plate check erboard method against 40 clinical isolates of Pseudomonas aeruginosa with various antibiotic resistance profiles. Fosfomycin/ciprofloxacin appeared to be the most effective combination (synergy 15%, addition 8 0%, indifference 5%), followed by fosfomycin/amikacin (synergy 7.5%, a ddition 52.5%, indifference 40%), fosfomycin/imipenem (addition 37%, i ndifference 63%), and fosfomycin/ceftazidime (addition 20%, indifferen ce 80%), The effects of the combinations were not significantly influe nced by the antibiotic susceptibility patterns of the strains.