M. Kern et al., INDUCTION OF ALDOSE REDUCTASE AND XYLITOL DEHYDROGENASE-ACTIVITIES INCANDIDA-TENUIS CBS-4435, FEMS microbiology letters, 149(1), 1997, pp. 31-37
Ln this study the ability of various sugars and sugar alcohols to indu
ce aldose reductase (xylose reductase) and xylitol dehydrogenase (xylu
lose reductase) activities in the yeast Candida tenuis was investigate
d. Both enzyme activities were induced when the organism was grown on
D-xylose or L-arabinose as well as on the structurally related sugars
D-arabinose or D-lyxose. Mixtures of D-xylose with the more rapidly me
tabolizable sugar D-glucose resulted in a decrease in the levels of bo
th enzymes formed. These results show that the utilization of D-xylose
by C. tenuis is regulated by induction and catabolite repression. Fur
thermore, the different patterns of induction on distinct sugars sugge
st that the synthesis of both enzymes is not under coordinate control.