INDUCTION OF ALDOSE REDUCTASE AND XYLITOL DEHYDROGENASE-ACTIVITIES INCANDIDA-TENUIS CBS-4435

Citation
M. Kern et al., INDUCTION OF ALDOSE REDUCTASE AND XYLITOL DEHYDROGENASE-ACTIVITIES INCANDIDA-TENUIS CBS-4435, FEMS microbiology letters, 149(1), 1997, pp. 31-37
Citations number
18
Categorie Soggetti
Microbiology
Journal title
ISSN journal
03781097
Volume
149
Issue
1
Year of publication
1997
Pages
31 - 37
Database
ISI
SICI code
0378-1097(1997)149:1<31:IOARAX>2.0.ZU;2-X
Abstract
Ln this study the ability of various sugars and sugar alcohols to indu ce aldose reductase (xylose reductase) and xylitol dehydrogenase (xylu lose reductase) activities in the yeast Candida tenuis was investigate d. Both enzyme activities were induced when the organism was grown on D-xylose or L-arabinose as well as on the structurally related sugars D-arabinose or D-lyxose. Mixtures of D-xylose with the more rapidly me tabolizable sugar D-glucose resulted in a decrease in the levels of bo th enzymes formed. These results show that the utilization of D-xylose by C. tenuis is regulated by induction and catabolite repression. Fur thermore, the different patterns of induction on distinct sugars sugge st that the synthesis of both enzymes is not under coordinate control.