We use a Markov model to calculate the expected medical, disability, e
mployee replacement, life insurance, and pension costs to a business f
irm for an HIV-infected employee. This analysis differs from previous
HIV/AIDS cost analyses because we take the perspective of a business f
irm rather than of society, and we focus on the expected costs over a
time frame relevant for business decision making. The maximum expected
five-year cost to a business firm for an HIV-infected employee is est
imated at $32,000, with an average expected cost of $17,000. These exp
ected employment-based costs are less than the lifetime medical AIDS c
osts to society for an individual, which are estimated at more than $8
5,000. Employment-based costs are most influenced by the type of benef
its provided under employer-based health insurance plans.