BILIODIGESTIVE SHUNT EVOKES HYPERCCKEMIA AND TROPHIC EFFECTS IN THE RAT PANCREAS, BUT NOT IN THE LIVER OR GASTROINTESTINAL-TRACT

The influence of bile on the release of cholecystokinin (CCK) and, the reby, on the regulation of exocrine pancreatic function and growth is unsettled. The aim of this study was to elucidate the effect of long-t erm diversion of bile from the upper small intestine on CCK release an d on the pancreas, liver, and gastrointestinal tract. A surgical bilio digestive shunt was performed in rats, diverting the bile flow directl y to the middle of the small intestine. The animals were killed after 4 or 12 weeks. Plasma CCK and trophic effects on the pancreas, liver, and gastrointestinal tract were determined, as were the trypsin and ch ymotrypsin contents in the intestine. The CCK concentration in plasma increased 10-fold at both time points studied. The pancreas doubled it s weight from 4 weeks onward. Also, pancreatic protein, DNA, and amyla se contents were increased throughout the study. The liver and gastroi ntestinal tract were unaffected. Intraluminal bile plays a role in the feedback regulation of CCK release and is involved in this way in the control of pancreatic growth but has no similar effects on the liver or gastrointestinal tract.