A GENERAL-APPROACH TOWARDS 2-SUBSTITUTED 3-HYDROXY PROPANOATES - APPLICATION TO THE SYNTHESIS OF METHYL TROPINATE

Authors
IMOGAI H LARCHEVEQUE M
Citation
H. Imogai et M. Larcheveque, A GENERAL-APPROACH TOWARDS 2-SUBSTITUTED 3-HYDROXY PROPANOATES - APPLICATION TO THE SYNTHESIS OF METHYL TROPINATE, Tetrahedron : asymmetry, 8(6), 1997, pp. 965-972
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
6
Year of publication
1997
Pages
965 - 972
Database
ISI
SICI code
0957-4166(1997)8:6<965:AGT23P>2.0.ZU;2-1
Abstract
Enantiomerically pure R or S 2-substituted 3-hydroxy propanoates may b e prepared by regioselective BF3 promoted opening of homochiral styren e oxide by lithium cyanocuprates followed by oxidative cleavage of the aromatic moiety with catalytic ruthenium trichloride. (C) 1997 Elsevi er Science Ltd.