Sp. Liang et al., EFFECTS OF CLOMETHIAZOLE ON RADIAL-ARM MAZE PERFORMANCE FOLLOWING GLOBAL FOREBRAIN ISCHEMIA IN GERBILS, Brain research, 751(2), 1997, pp. 189-195
The functional and neuroanatomical protective effects of clomethiazole
(CMZ) were examined in an animal model of global forebrain ischemia.
Gerbils underwent sham-surgery or were rendered ischemic by the applic
ation of aneurysm clips to both carotid arteries for 6 min. Three trea
tment groups received CMZ (50 mg/kg, 100 mg/kg, or 150 mg/kg) 30 min b
efore ischemia, and one group was given; 150 mg/kg of CMZ 30 min after
ischemia. Following recovery, the gerbils were tested in a radial-arm
maze to assess memory functions. Histological evaluation was assessed
blindly using a percentile scoring system. The results indicate that
pre-ischemic treatment with 100 mg/kg and 150 mg/kg of CMZ reduced bra
in damage and working memory errors significantly. Treatment dosage of
150 mg/kg of CMZ was the most effective in preventing neuronal damage
in the hippocampus and eliminating the working memory deficit typical
ly induced by ischemia.