SPECTROPHOTOMETRIC DETERMINATION OF THYROXINE SODIUM IN DRUG FORMULATIONS

Authors
QURESHI SZ HELALEH MI RAHMAN N JAMHOUR RMAQ
Citation
Sz. Qureshi et al., SPECTROPHOTOMETRIC DETERMINATION OF THYROXINE SODIUM IN DRUG FORMULATIONS, Chemia Analityczna, 42(1), 1997, pp. 65-69
Citations number
17
Categorie Soggetti
Chemistry Analytical
Journal title
Chemia Analityczna → ACNP
ISSN journal
00092223
Volume
42
Issue
1
Year of publication
1997
Pages
65 - 69
Database
ISI
SICI code
0009-2223(1997)42:1<65:SDOTSI>2.0.ZU;2-Q
Abstract
The spectrophotometric determination of thyroxine sodium is based on r eaction of its amine group with nitrous acid (produced by reaction of mineral acid with sodium nitrite) in an ice cold bath (0-5 degrees C). It produces a stable yellow coloured compound under experimental cond itions with lambda(max) 420 nm. Beer's law is obeyed in the concentrat ion range 10-90 mu g ml(-1) with molar absorptivity 4.0x10(3) l mol(-1 ) cm(-1).