SUCCESSFUL IMMUNOMODULATION WITH INTRAVENOUS GAMMA-GLOBULIN AND CYCLOPHOSPHAMIDE IN AN ALLOIMMUNIZED HEART-TRANSPLANT RECIPIENT

Authors
DEMARCO T DAMON LE COLOMBE B KEITH F CHATTERJEE K GAROVOY MR
Citation
T. Demarco et al., SUCCESSFUL IMMUNOMODULATION WITH INTRAVENOUS GAMMA-GLOBULIN AND CYCLOPHOSPHAMIDE IN AN ALLOIMMUNIZED HEART-TRANSPLANT RECIPIENT, The Journal of heart and lung transplantation, 16(3), 1997, pp. 360-365
Citations number
46
Categorie Soggetti
Cardiac & Cardiovascular System",Transplantation,"Respiratory System
Journal title
The Journal of heart and lung transplantation → ACNP
ISSN journal
10532498
Volume
16
Issue
3
Year of publication
1997
Pages
360 - 365
Database
ISI
SICI code
1053-2498(1997)16:3<360:SIWIGA>2.0.ZU;2-X
Abstract
A highly human leukocyte antigen-sensitized heart transplant candidate underwent immunomodulation with intravenous gamma globulin and cyclop hosphamide. His panel reactive antibody screen fell from 64% to 14%. H e underwent successful orthotopic heart transplantation with a histoin compatible, T-cell cross-match-negative heart without the development of hyperacute rejection. The combination of intravenous gamma globulin and cyclophosphamide may be a simple and effective means to overcome the human leukocyte antigen-barrier in sensitized heart transplant can didates.