DEVELOPMENT OF A HYBRID QUANTUM-CHEMICAL AND MOLECULAR MECHANICS METHOD WITH APPLICATION TO SOLVENT EFFECTS ON THE ELECTRONIC-SPECTRA OF URACIL AND URACIL DERIVATIVES

A method for molecular dynamics (MD), Monte Carlo (MC), and energy min imization simulation utilizing a Hamiltonian that is divided into two parts is described. One part is treated with a quantum mechanical Hami ltonian, typically a small part of the simulated system that comprises the chromophore. The other part is treated with a classical mechanica l Hamiltonian. This partitioning of the system allows us to simulate, for example, not only electronic spectroscopy but also chemical reacti ons when a bond is broken or to explore the excited state potential en ergy surface. The particular choice of the quantum mechanical Hamilton ian, the intermediate neglecting of differential overlap (INDO) model Hamiltonian, also offers the possibility of simulating systems that co ntain a transition metal, which only rarely have been accessible with traditional MD and MC methods. Test calculations on small systems are presented together with an investigation of the photophysics of uracil and 1,3-dimethyluracil.