POLYSTYRENE-SUPPORTED HYDROXAMIC DITHIOCARBONIC ANHYDRIDES - A NEW CLASS OF ACYL TRANSFER REAGENTS

Polystyrene-supported hydroxamic dithiocarbonic anhydrides were develo ped as a new class of regenerable solid phase reagents for acylating a mino groups selectively. The reagent was prepared from crosslinked pol ystyrene support by a series of polymer analogous reactions. The cross linking agents used were divinylbenzene (DVB) and ethyleneglycol dimet hacrylate (EGDMA). The reagents were found to transfer their acyl grou ps to amines in solution at room temperature, yielding a solution of t he corresponding amides. The influence of solvent, temperature, molar ratio and duration of reaction were studied to find out the optimum co nditions. The spent reagent can be regenerated several times by a simp le reaction, without significant loss in activity.