A NATIONAL COLLABORATIVE STUDY OF THE IN-VITRO ACTIVITY OF ORAL CEPHALOSPORINS END LORACARBEF (LY-163892)

A national collaborative study involving the laboratories of 17 Austra lian hospitals examined the in vitro activity of loracarbef, cefaclor, cephalexin, amoxycillin and amoxycillin/clavulanate against 2661 rece ntly isolated common bacterial pathogens, Loracarbef was the most acti ve agent against Escherichia coli (MIC(90) = 1 mg/l) and had activity comparable to other agents against Klebsiella pneumoniae and Proteus m irabilis, Like the oral cephalosporins, it had no activity against spe cies of Enterobacter and Serratia, beta-lactamase-producing Staphyloco ccus aureus and Haemophilus influenzae were moderately sensitive to lo racarbef (MIC(90) = 8 mg/l for both species). Streptococcus pneumoniae was moderately sensitive to loracarbef (MIC(90) = 2 mg/l) but strains which were insensitive to penicillin were often highly resistant.