Prenatal invasive diagnosis of genetic conditions in the Netherlands i
s well organised, based on uniform indications and has a sound financi
al structure. Facilities for fetal karyotyping and DNA analysis are av
ailable in the 8 academic centres. Prenatal diagnosis of metabolic dis
eases is mainly carried out in Rotterdam. Amniocentesis, transcervical
and transabdominal chorionic villus sampling are carried out in all c
entres, including 4 subcentres. The national Working Party on Prenatal
Diagnosis started in 1985 and is a useful platform for all obstetrici
ans and geneticists involved in prenatal diagnosis.