AN EFFICIENT STEREOSELECTIVE SYNTHESIS OF 1-ALPHA,24(R)-DIHYDROXYVITAMIN D-3 BY THE DIENYNE ROUTE

Authors
FALL Y TORNEIRO M CASTEDO L MOURINO A
Citation
Y. Fall et al., AN EFFICIENT STEREOSELECTIVE SYNTHESIS OF 1-ALPHA,24(R)-DIHYDROXYVITAMIN D-3 BY THE DIENYNE ROUTE, Tetrahedron, 53(13), 1997, pp. 4703-4714
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
13
Year of publication
1997
Pages
4703 - 4714
Database
ISI
SICI code
0040-4020(1997)53:13<4703:AESSO1>2.0.ZU;2-1
Abstract
1 alpha,24(R)-Dihydroxyvitamin D-3 (5e) was synthesized. The key step in the preparation of the side-chain was opening of the chiral epoxide 10 by the alpha-anion of the nitrile 9, The triene system was synthes ized by the dienyne route. (C) 1997 Elsevier Science Ltd.