B. Altava et al., POLYAZA[N]PARACYCLOPHANES AS SYNTHETIC MODELS OF ZN CONTAINING ENZYMES - THE ROLE OF A NON COORDINATED NITROGEN ATOM IN THE PROXIMITY OF THE METAL, Tetrahedron, 53(13), 1997, pp. 4751-4762
2,6,9,13-Tetraaza[14]paracyclophane (3, B323) represents a simple mode
l for Zn containing enzymes like HCAII which possess additional reacti
ve groups in the proximity of the metal center. The Zn2+.3 complex sho
ws notable catalytic activity for the hydrolysis of p-nitrophenyl acet
ate. Structural modifications of 3 which affect to the non coordinated
nitrogen atom greatly modify the catalytic activity of the receptor.
(C) 1997 Elsevier Science Ltd.