POLYAZA[N]PARACYCLOPHANES AS SYNTHETIC MODELS OF ZN CONTAINING ENZYMES - THE ROLE OF A NON COORDINATED NITROGEN ATOM IN THE PROXIMITY OF THE METAL

Authors
ALTAVA B BURGUETE MI LUIS SV MIRAVET JF GARCIAESPANA E MARCELINO V SORIANO C
Citation
B. Altava et al., POLYAZA[N]PARACYCLOPHANES AS SYNTHETIC MODELS OF ZN CONTAINING ENZYMES - THE ROLE OF A NON COORDINATED NITROGEN ATOM IN THE PROXIMITY OF THE METAL, Tetrahedron, 53(13), 1997, pp. 4751-4762
Citations number
61
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
13
Year of publication
1997
Pages
4751 - 4762
Database
ISI
SICI code
0040-4020(1997)53:13<4751:PASMOZ>2.0.ZU;2-C
Abstract
2,6,9,13-Tetraaza[14]paracyclophane (3, B323) represents a simple mode l for Zn containing enzymes like HCAII which possess additional reacti ve groups in the proximity of the metal center. The Zn2+.3 complex sho ws notable catalytic activity for the hydrolysis of p-nitrophenyl acet ate. Structural modifications of 3 which affect to the non coordinated nitrogen atom greatly modify the catalytic activity of the receptor. (C) 1997 Elsevier Science Ltd.