MYOGLOBIN SIGNAL AS AN NMR TISSUE THERMOMETER - IMPLICATION FOR HYPERTHERMIA TREATMENT OF TUMORS

Authors
CHUNG YG JUE T
Citation
Yg. Chung et T. Jue, MYOGLOBIN SIGNAL AS AN NMR TISSUE THERMOMETER - IMPLICATION FOR HYPERTHERMIA TREATMENT OF TUMORS, Biochimica et biophysica acta. Molecular basis of disease, 1226(1), 1994, pp. 31-36
Citations number
19
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular basis of disease → ACNP
ISSN journal
09254439
Volume
1226
Issue
1
Year of publication
1994
Pages
31 - 36
Database
ISI
SICI code
0925-4439(1994)1226:1<31:MSAANT>2.0.ZU;2-S
Abstract
Measuring local tissue temperature is critical in establishing a ratio nal approach for hyperthermia treatment of tumors. We have found that the heme signals of myoglobin provide a unique basis for NMR thermomet ry in vivo. In particular the 5-methyl heme signal of MbCN exhibits a sharp, temperature-dependent resonance that is distinguishable in the tissue spectrum. Its calibrated chemical shift can then reflect the lo cal tissue temperature in vivo.