Yg. Chung et T. Jue, MYOGLOBIN SIGNAL AS AN NMR TISSUE THERMOMETER - IMPLICATION FOR HYPERTHERMIA TREATMENT OF TUMORS, Biochimica et biophysica acta. Molecular basis of disease, 1226(1), 1994, pp. 31-36
Measuring local tissue temperature is critical in establishing a ratio
nal approach for hyperthermia treatment of tumors. We have found that
the heme signals of myoglobin provide a unique basis for NMR thermomet
ry in vivo. In particular the 5-methyl heme signal of MbCN exhibits a
sharp, temperature-dependent resonance that is distinguishable in the
tissue spectrum. Its calibrated chemical shift can then reflect the lo
cal tissue temperature in vivo.