Sm. Lele et al., ECCRINE SYRINGOFIBROADENOMA SURROUNDING A SQUAMOUS-CELL CARCINOMA - ACASE-REPORT, Journal of cutaneous pathology, 24(3), 1997, pp. 193-196
A 91-year-old man presented with a 9.0 x 7.0 cm exophytic mass on the
dorsum of the right foot, surrounded by a scaling hyperkeratotic plaqu
e-like lesion that had been present for many years. He had similar lon
g-standing hyperkeratotic plaque-like lesions on both legs. Histopatho
logic examination of the exophytic mass revealed a well-differentiated
squamous cell carcinoma surrounded by an eccrine syringofibroadenoma
(ESFA). Histochemistry, immunohistochemistry and electron microscopy s
upport this diagnosis. To our knowledge, this is the only reported cas
e of ESFA being intimately associated with a malignant neoplasm.