GLIAL CHORISTOMA IN THE ORAL CAVITY - HISTOPATHOLOGIC AND IMMUNOHISTOCHEMICAL FEATURES

This report describes the morphologic and immunohistochemical features of two cases of glial choristoma arising in the palate. The bulk of t he lesions consisted of mature neuroglial tissue admired with salivary glands, adipose tissue and lymphoid aggregates in case 1 and of carti lage, bone and foci of smooth muscle cells in case 2. In addition, cas e 2 showed choroid plexus and melanin-containing epithelium. Neuroglia l tissue was intensely positive for CD57 as well as for glial fibrilla ry acidic protein, S-100 protein and vimentin. Neuron-specific enolase and neurofilament were focally or weakly positive. Proliferating cell nuclear antigen was negative in case 1 but sparsely positive in case 2, These features reflect the fact that glial choristoma is a developm ental malformation of heterotopic central nervous tissue with limited growth potential.