Helicobacter species have recently been recognized as important pathog
ens in human gastrointestinal disease. Helicobacter species evidently
play a role in gastrointestinal disease in some animal species, such a
s ferrets, cheetahs, pigs, dogs, and cats. The pathogenicity of Helico
bacter organisms may result from their unusual ability to survive the
highly acidic environment of the stomach. Eradication of Helicobacter
infection from human ulcer patients requires combinations of antimicro
bials and other drugs but has resulted in significantly reduced recurr
ence rates of gastroduodenal ulceration and gastritis. Helicobacter py
lori has been associated with gastric adenocarcinoma in humans. Veteri
nary gastroenterologists and microbiologists are currently investigate
d the potential role of Helicobacter species in disease of dogs and ca
ts.