APPLICATION OF 7-ENDO, 8-ENDO AND 9-ENDO RADICAL CYCLIZATIONS TO THE SYNTHESIS OF CONFORMATIONALLY CONSTRAINED AMINO-ACIDS AND COMPARISON WITH THE CORRESPONDING HECK REACTIONS
Se. Gibson et al., APPLICATION OF 7-ENDO, 8-ENDO AND 9-ENDO RADICAL CYCLIZATIONS TO THE SYNTHESIS OF CONFORMATIONALLY CONSTRAINED AMINO-ACIDS AND COMPARISON WITH THE CORRESPONDING HECK REACTIONS, Chemical communications, (6), 1997, pp. 637-638
Radical cyclisation of substrates 1a-c proceeds smoothly to give seven
-, eight- and nine-membered rings 3a-c in 73, 71 and 52% yield respect
ively; comparison of these results with those obtained using the intra
molecular Heck reactions suggests that the two cyclisation methods pro
vide complementary approaches to medium-sized rings.