STUDY OF IA-ANTIGEN AND LFA-1-ANTIGENS EX PRESSION IN PATIENTS WITH UVEITIS

Studies of the surface markers of Ia- and LFA-1-antigens, carried out in 111 patients with uveitis by indirect immunofluorescence with the u se of ICO-1 and ICO-11 monoclonal antibodies, revealed changed counts of the cells, expressing these antigens. The least counts of Ia- and L FA-1-positive cells was found in the patients with generalized uveitis , vs. other clinical forms of the condition (29.5 vs. 27.9 %, respecti vely). Increased counts of la- and LFA-1-positive cells were more freq uent in the patients with chorioretinitis and anterior uveitis (32.1, 29.4 and 61.5 and 64.7 %, respectively). A relationship has been estab lished between Ia- and LFA-1-presenting cells deficiency and activity, high incidence of uveitis recurrences, and prednisolone therapy. A co mplex structure of correlations between Ia- and LFA-1-antigen-presenti ng cells and the levels of T8 suppressor cytotoxic cells, B lymphocyte s in various periods of uveitis activity and its different clinical fo rms was found. In contrast to indomethacin, prednisolone was found to suppress the counts of Ia- and LFA-1-containing cells, this suggesting administration of prednisolone in complex with immunostimulants: