STUDY OF ANTI-HIV ACTIVITY OF YEAST RNA-T ILORONE MOLECULAR-COMPLEX

Anti-HIV activity of the molecular complex forming during interaction between yeast RNA and tilorone was studied in vitro on the models of a cute and chronic infection. Addition of this agent to the cells infect ed with HIV-1/IIIB and HIV-1/BRU decreased the virus reproduction cont rolled by assessing the viability of cells, syncytium production, and accumulation of p24 antigen in culture medium. The authors hypothesize that the detected anti-HIV effect is due to its capacity to produce t ype I interferon and direct antiviral action.