Data on the chemistry of azafluorenes (indenopyridines) over the past
20 years are surveyed. Methods for the synthesis of azafluorene isomer
s with the nitrogen atom in all the possible positions are considered.
The main reactions of azafluorenes are analysed. Their reactivity is
determined by the presence and mutual influence of the two fused rings
of different natures (benzene and pyridine rings) as well as by the o
rder of conjugation of benzene and pyridine fragments. The main transf
ormations of substituents occupying various positions of the azafluore
ne system are considered. Data on the natural occurrence of azafluoren
es, biological activities of their derivatives, and on the structure a
nd physicochemical properties of azafluorenes and their derivatives ar
e presented.