M. Minkov et al., THE RESPONSE TO INITIAL TREATMENT AS A FA VORABLE PROGNOSIS FACTOR INLANGERHANS CELL POLYSYSTEMIC HISTIOCYTOSIS IN CHILDREN, Gematologia i transfuziologia, 41(3), 1996, pp. 13-17
Prognostic significance of various clinical and laboratory factors has
been assessed in 88 patients with Langerhans polysystemic histiocytos
is (PSH). A statistically significant relationship was found between t
he number of the affected systems, liver dysfunction and the disease o
utcome. However, these factors did not allow prognosis in each individ
ual case. Valid prognosis was feasible in estimation of the response t
o initial treatment: in failure of the initial treatment the lethal ou
tcome occurred in 90% of cases. Thus, the response to initial treatmen
t may be used as an independent and highly informative prognostic fact
or valuable in therapy prognosis and correction in PSH patients at ear
ly stages of the treatment.