CRITICAL COMPONENTS OF THE FEMALE REPRODUCTIVE PATHWAY ARE SUPPRESSEDBY THE ANGIOGENESIS INHIBITOR AGM-1470

Angiogenesis, the growth of new blood vessels, occurs normally in fema le reproductive organs. We tested the hypothesis that angiogenesis inh ibition may affect fertility by studying the reproductive system in ei ther pregnant or nonpregnant cycling mice after treatment with the ang iogenesis inhibitor AGM-1470. Administration of AGM-1470 to pregnant m ice resulted in complete failure of embryonic growth due to interferen ce with decidualization, placental and yolk sac formation, and embryon ic vascular development. When nonpregnant cycling female mice were chr onically treated with AGM-1470, inhibition of endometrial maturation a nd corpora lutea was observed. These data suggest that processes in re production can be controlled through angiogenesis inhibition.