N. Klauber et al., CRITICAL COMPONENTS OF THE FEMALE REPRODUCTIVE PATHWAY ARE SUPPRESSEDBY THE ANGIOGENESIS INHIBITOR AGM-1470, Nature medicine, 3(4), 1997, pp. 443-446
Citations number
13
Categorie Soggetti
Medicine, Research & Experimental",Biology,"Cell Biology
Angiogenesis, the growth of new blood vessels, occurs normally in fema
le reproductive organs. We tested the hypothesis that angiogenesis inh
ibition may affect fertility by studying the reproductive system in ei
ther pregnant or nonpregnant cycling mice after treatment with the ang
iogenesis inhibitor AGM-1470. Administration of AGM-1470 to pregnant m
ice resulted in complete failure of embryonic growth due to interferen
ce with decidualization, placental and yolk sac formation, and embryon
ic vascular development. When nonpregnant cycling female mice were chr
onically treated with AGM-1470, inhibition of endometrial maturation a
nd corpora lutea was observed. These data suggest that processes in re
production can be controlled through angiogenesis inhibition.