Sick-building syndrome (SBS) is an increasingly common problem. Althou
gh objective physiological abnormalities are not generally found and p
ermanent sequelae are rare, the symptoms of SBS can be uncomfortable,
even disabling, and whole workplaces can be rendered non-functional. I
n assessment of patients with SBS complaints, specific building-relate
d illnesses suggested by history or physical examination should be rul
ed out. On-site assessment of buildings is extremely useful. Treatment
involves both the patient and the building. Whenever possible, change
s such as ventilation improvements and reduction of sources of environ
mental contamination should be initiated even if specific aetiological
agents have not been identified.