INCIDENCE OF INFECTIOUS-DISEASE AND THE LICENSURE OF IMMUNOBIOLOGICS IN THE UNITED-STATES

Introduction: Our objective was to investigate the relationship of vac cine or toroid licensure with the incidence of the target disease in t he United States. Methods: We used a historical correlational study de sign with outcome measures of the national incidence and elimination r ate of polio, pertussis, diphtheria, and measles as well as the New Yo rk City incidence and elimination rate of mumps, rubella, and tetanus. Results: The licensure of pertussis, measles, polio, mumps, and rubel la vaccine was followed by an increase in the elimination rate of dise ase. The elimination rates of diphtheria and tetanus apparently worsen ed following the licensure of the respective toxoids. Conclusions: His torical data provide evidence of proof of efficacy of mass immunicatio n for measles, polio, rubella, mumps, and pertussis, but not for dipht heria or tetanus.