IN-VITRO AND IN-VIVO ANTICHLAMYDIAL ACTIVITIES OF HSR-903, A NEW FLUOROQUINOLONE ANTIBIOTIC

The in vitro and in vivo antichlamydial activities of HSR-903 were inv estigated. The MICs of HSR-903 for different species of chlamydia were 0.016 to 0.063 mu g/ml, which were superior to those of conventional fluoroquinolones. The therapeutic effect of HSR-903 in experimental mo use Chlamydia psittaci pneumonia was also excellent and almost equal t o that of minocycline and superior to that of ofloxacin. These results indicate that HSR-903 may be useful in the treatment of respiratory i nfections caused by chlamydiae.