EARLY EFFECTS OF GANCICLOVIR THERAPY ON THE QUANTITY OF CYTOMEGALOVIRUS DNA IN LEUKOCYTES OF IMMUNOCOMPROMISED PATIENTS

Authors
BOIVIN G QUIRK MR KRINGSTAD BA GERMAIN M JORDAN MC
Citation
G. Boivin et al., EARLY EFFECTS OF GANCICLOVIR THERAPY ON THE QUANTITY OF CYTOMEGALOVIRUS DNA IN LEUKOCYTES OF IMMUNOCOMPROMISED PATIENTS, Antimicrobial agents and chemotherapy, 41(4), 1997, pp. 860-862
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
4
Year of publication
1997
Pages
860 - 862
Database
ISI
SICI code
0066-4804(1997)41:4<860:EEOGTO>2.0.ZU;2-K
Abstract
The cytomegalovirus (CMV) DNA load in leukocytes was measured in 26 im munocompromised patients with CMV disease before and after 10 days of intravenous ganciclovir therapy. Before therapy, the circulating DNA b urden of bone marrow transplant recipients was significantly lower tha n that of other transplant or AIDS patients. Ganciclovir induction the rapy significantly decreased the viral DNA load in the leukocyte popul ations of most patients.