EFFECTS OF RP-55778, A TUMOR-NECROSIS-FACTOR-ALPHA SYNTHESIS INHIBITOR, ON ANTIVIRAL ACTIVITY OF DIDEOXYNUCLEOSIDES

Citation
P. Clayette et al., EFFECTS OF RP-55778, A TUMOR-NECROSIS-FACTOR-ALPHA SYNTHESIS INHIBITOR, ON ANTIVIRAL ACTIVITY OF DIDEOXYNUCLEOSIDES, Antimicrobial agents and chemotherapy, 41(4), 1997, pp. 875-877
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
ISSN journal
00664804
Volume
41
Issue
4
Year of publication
1997
Pages
875 - 877
Database
ISI
SICI code
0066-4804(1997)41:4<875:EORATS>2.0.ZU;2-M
Abstract
Tumor necrosis factor alpha (TNF-alpha) is overexpressed during human immunodeficiency virus (HIV) infection. RP 55778, a TNF-alpha synthesi s inhibitor, decreases HIV replication in monocytes/macrophages. Thera peutic use of RP 55778 in vivo, like that of other biological response modifiers, would theoretically require association with dideoxynucleo sides. We have evaluated here the combinatory effects of zidovudine (A ZT) or dideoxyinosine (ddI) and RP 55778. This TNF-alpha inhibitor ant agonizes the antiviral effects of both dideoxynucleosides, especially AZT. The more favorable anti-HIV activity of ddI in resting cells may explain these unequal degrees of antagonism.